What are Emerging Therapies for Acetaminophen and NSAID Toxicity? Gastroprotective agents to prevent or treat gastric ulcers (eg, proton pump inhibitors ).If acute liver failure occurs, intensive supportive therapy or liver transplantation may be required.Activated charcoal to absorb excess drug.N-acetylcysteine, administered either intravenously or orally, to restore glutathione levels.What are Conventional Medical Treatments for Acetaminophen and NSAID Toxicity? Note: If you suspect an acetaminophen overdose immediately call 911 or the National Poison Control Center (1-80).

What are Signs and Symptoms of Acetaminophen and NSAID Toxicity? Pay specific attention if you are taking more than one medication-many contain acetaminophen and inadvertent combination can easily cause an overdose. For an adult, the maximum recommended single dose of acetaminophen is 1 gram and the maximum dose in a 24-hour period is 4 grams. Note: Always read dosing instructions and warnings on every medication. Renal or hepatic impairment (and other pre-existing medical conditions).What are Risk Factors for Acetaminophen and NSAID Toxicity? Natural interventions such as N-acetylcysteine and silymarin may help prevent acetaminophen and NSAID toxicity. Their risk profiles vary depending on their cellular targets. NSAIDs can cause toxicity in the gastrointestinal tract, kidneys, and cardiovascular system. Acetaminophen overdose can cause acute liver failure, and in some cases, renal failure. Excess levels overwhelm the liver’s innate detoxification system by depleting levels of glutathione, the ubiquitous cellular antioxidant. Overdosing on acetaminophen is not uncommon, and acetaminophen accounts for up to 50% of all adult cases of acute liver failure in the United States.Īcetaminophen can be toxic to the liver and kidneys. What is Acetaminophen and NSAID Toxicity?Īcetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) (eg, aspirin, ibuprofen) are widely used as analgesics and antipyretics (fever-reducers).

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